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Marco Giovannini Selected Research

Neurilemmoma (Schwannoma)

11/2019Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo.
1/2019Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2-associated schwannomas reveals differences in efficacy and drug resistance development.
1/20182016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.
10/2017The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.
1/2016An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth.
1/2015Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.
4/2014mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma.
7/2013Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.
8/2011Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.
2/2010Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
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Marco Giovannini Research Topics

Disease

47Neoplasms (Cancer)
01/2022 - 10/2002
21Neurofibromatosis 2 (Neurofibromatosis Type II)
01/2022 - 08/2002
17Neurilemmoma (Schwannoma)
11/2019 - 08/2002
10Carcinogenesis
11/2016 - 06/2003
8Pain (Aches)
01/2016 - 01/2004
7Meningioma (Meningiomas)
06/2017 - 07/2007
6Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2018 - 05/2011
6Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
01/2018 - 12/2013
6Neurofibromatoses (Neurofibromatosis)
01/2018 - 04/2003
5Schwannomatosis
01/2022 - 03/2013
5Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2018 - 01/2004
4Neoplasm Metastasis (Metastasis)
11/2020 - 05/2003
4Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
09/2017 - 01/2014
4Acoustic Neuroma (Acoustic Neurinoma)
06/2017 - 06/2009
4Hematologic Neoplasms (Hematological Malignancy)
01/2016 - 10/2009
4Myelodysplastic Syndromes (Myelodysplastic Syndrome)
02/2015 - 07/2013
4Mesothelioma
02/2011 - 04/2003
3Glioma (Gliomas)
01/2018 - 07/2007
3Non-Hodgkin Lymphoma (Lymphosarcoma)
08/2013 - 06/2008
3Neurofibrosarcoma (MPNST)
01/2013 - 06/2009
3Renal Insufficiency (Renal Failure)
06/2012 - 06/2010
3Malignant Mesothelioma
02/2011 - 04/2003
3Mucositis
10/2009 - 08/2006
2Cancer Pain
01/2016 - 09/2011
2Hemolytic Anemia
05/2014 - 10/2008
2Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
07/2012 - 07/2009
2Chronic Kidney Failure (Chronic Renal Failure)
05/2011 - 05/2011
2Hemorrhage
01/2011 - 03/2009
2Thrombocytopenia (Thrombopenia)
01/2011 - 04/2009
2Multiple Myeloma
03/2010 - 04/2009
2Leukemia
02/2010 - 04/2009
2Stomatitis
10/2009 - 01/2004
2Nervous System Neoplasms (Neoplasms, Nervous System)
07/2007 - 08/2002
2Ascites
12/2005 - 06/2003
1Osteosarcoma (Osteogenic Sarcoma)
11/2020
1Legius syndrome
01/2018
1Inborn Genetic Diseases (Disease, Hereditary)
01/2018
1Musculoskeletal Abnormalities
01/2018
1Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)
10/2017
1Neuroblastoma
06/2017
1Sarcoma (Soft Tissue Sarcoma)
06/2017
1Ulcer
01/2017
1Inflammation (Inflammations)
11/2016
1Hepatomegaly
11/2016
1Glucosephosphate Dehydrogenase Deficiency
03/2016
1Hearing Loss (Hearing Impairment)
01/2016

Drug/Important Bio-Agent (IBA)

27Neurofibromin 2 (Merlin)IBA
11/2020 - 08/2002
7Proteins (Proteins, Gene)FDA Link
11/2019 - 01/2007
7Analgesics (Analgesic Drugs)IBA
01/2016 - 01/2004
6Rituximab (Mabthera)FDA Link
03/2016 - 10/2008
4Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2019 - 05/2008
4Azacitidine (5 Azacytidine)FDA Link
09/2017 - 01/2014
4Opioid Analgesics (Opioids)IBA
01/2016 - 08/2006
3Uvitex SWN (SWN)IBA
01/2022 - 06/2017
3DecitabineFDA Link
01/2018 - 01/2017
3EverolimusFDA Link
10/2017 - 04/2015
3Biomarkers (Surrogate Marker)IBA
06/2017 - 10/2002
3eltrombopagFDA Link
03/2016 - 03/2014
3AsbestosIBA
02/2011 - 06/2003
2IntegrinsIBA
11/2020 - 08/2011
2Neurofibromin 1 (Neurofibromin)IBA
01/2018 - 01/2018
2Mechanistic Target of Rapamycin Complex 1IBA
04/2015 - 04/2014
2TOR Serine-Threonine KinasesIBA
04/2015 - 04/2014
2romiplostimFDA Link
10/2014 - 03/2014
2moesinIBA
12/2011 - 08/2011
2ezrinIBA
12/2011 - 08/2011
2radixinIBA
12/2011 - 08/2011
2Oxycodone (Oxycontin)FDA LinkGeneric
06/2010 - 09/2007
2Tumor Suppressor Protein p14ARF (p14ARF)IBA
01/2008 - 12/2005
2Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
07/2007 - 01/2007
1Integrin alpha4beta1 (VLA-4)IBA
11/2020
1Messenger RNA (mRNA)IBA
11/2019
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
11/2019
1Caspase 9IBA
11/2019
1Staphylococcal Protein A (Protein A)IBA
11/2019
1Adenosine Triphosphate (ATP)IBA
11/2019
1Caspase 3 (Caspase-3)IBA
11/2019
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2019
1trametinibIBA
01/2019
1DNA (Deoxyribonucleic Acid)IBA
01/2019
1Syk KinaseIBA
01/2018
1nilotinibFDA Link
10/2017
1Bevacizumab (Avastin)FDA Link
10/2017
1Lapatinib (GW572016)FDA Link
10/2017
1Hemoglobins (Hemoglobin)IBA
01/2017
1CyclinsIBA
11/2016
1CytokinesIBA
11/2016
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2016
1SteroidsIBA
03/2016

Therapy/Procedure

19Therapeutics
10/2017 - 10/2002
3Aftercare (After-Treatment)
10/2017 - 01/2006
3Radiotherapy
10/2017 - 09/2009
3Salvage Therapy
01/2017 - 06/2008
3Pain Management
06/2012 - 08/2006
2Palliative Care (Palliative Therapy)
01/2014 - 03/2009
2Drug Therapy (Chemotherapy)
03/2013 - 10/2009
2Hematopoietic Stem Cell Transplantation
01/2013 - 10/2009
2Transplantation
01/2013 - 01/2004
2Stem Cell Transplantation
03/2009 - 09/2007
1Intravenous Injections
11/2020